A good correlation was considered for a value >0.60. A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Results: , Gladman DD et al. 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; SLE is an immune-mediated multisystemic disease characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares [1, 2]. Once two investigators (E.C., M.P.) Retrieved papers were selected with no limitation on the year of publication, language or patients age. Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. Please check for further notifications by email. Beaton DE Direkt zum Inhalt springen . Piga M 2) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99], with the SLAM in 4 studies (r=0.470.65) [35, 76, 84, 99], with LAI in 2 studies (r=0.640.75) [68, 84], with BILAG in 2 studies (r=0.610.62) [35, 84] and with ECLAM in 2 studies (r=0.580.65) [35, 84]. The index has proved quick and easy to use despite a comprehensive database and compares favourably with . PGA - Lupus Research Construct validity was recognized in 21 studies [2, 10, 11, 23, 24, 2629, 35, 47, 52, 54, 65, 68, 76, 84, 88, 92, 99, 101]. All rights reserved. The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . A total of 91 articles were included in the study (Fig. et al. Prinsen CAC Mok CC The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. T1 - Associations between physicians' global assessment of disease activity and patient-reported outcomes in patients with systemic lupus erythematosus. , Klein-Gitelman MS , Alunno A Int J Environ Res Public Health. , Lerman RH et al. , Birmingham DJ Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). et al. Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. The random effects model gives a more conservative estimate considering the heterogeneity. Lai J-S SLE has protean and often complex manifestations, necessitating careful clinical assessment. In the second column, the definitions were reported according to the VAS used in the study. et al. The Physician Global Assessment (PGA) is a frequently used co-primary end point in psoriasis clinical trials. PDF Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv , Longenecker JC Aranow C In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. Intoduction to X 20 - Physician Global Assessment et al. TOTAL DOCUMENTS. et al. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. Pincus and colleagues conducted a study of . HHS Vulnerability Disclosure, Help Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. Bookshelf This concept includes content validity, face validity, construct validity and criterion validity. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). Petri M , Sjwall C Myelogram - correct answer NPO for 4-6 hours. Navarra SV Global Respiratory Devices Market Size, Growth, Source Analysis, Top The Validity of Patient and Physician Global Disease Activity , Fang H Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. SELENA SLEDAI4. et al. The aim of this systematic literature review is to describe and analyse the . , Gladman DD. ECG - correct answer no sleep the night before, meals allowed, no stimulants/tranquilizers for 24-48 hours before. However, it is important to remember that not all clinical problems reported by a lupus patient are due to the disease. , Francis S Elevation of erythrocyte sedimentation rate is associated with disease activity and damage accrual, The systemic lupus activity measure-revised, the Mexican systemic lupus erythematosus disease activity index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus, Small changes in outpatients lupus activity are better detected by clinical instruments than by laboratory tests, Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50, Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation, Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months, Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial, Psychological distress and changes in the activity of systemic lupus erythematosus, The rating scale preference measure as an evaluative measure in systemic lupus erythematosus, Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus, Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months, Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus, Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006, Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale, Autoantibodies against albumin in patients with systemic lupus erythematosus, Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry, Placebo-controlled randomized clinical trial of fish oils impact on fatigue, quality of life, and disease activity in systemic lupus erythematosus, Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus, Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis, Systemic lupus erythematosus disease activity index 2000 responder index-50: a reliable index for measuring improvement in disease activity, Testosterone patches in the management of patients with mild/moderate systemic lupus erythematosus, Turkish LupusPRO: cross-cultural validation study for lupus, Cross-cultural validation of a disease-specific patient-reported outcome measure for lupus in Philippines, Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity, The TNF locus is altered in monocytes from patients with systemic lupus erythematosus, Effect of pregnancy on disease flares in patients with systemic lupus erythematosus, Frequency of lupus flare in pregnancy: the Hopkins Lupus Pregnancy Center experience, Morbidity of systemic lupus erythematosus: role of race and socioeconomic status, Classification and definition of major flares in SLE clinical trials, Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study, COSMIN guideline for systematic reviews of patient-reported outcome measures, Validity and reliability in social science research, Understanding the minimum clinically important difference: a review of concepts and methods, Statistical significant change versus relevant or important change in (quasi) experimental design: some conceptual and methodological problems in estimating magnitude of intervention-related change in health services research, Minimum important difference between patients with rheumatoid arthritis: the patients perspective, Responsiveness and sensitivity to change of SLE disease activity measures, The Author(s) 2020. PGA0.3. Using the Physician Global Assessment in a clinical setting to - PubMed , Maxwell LJ Provide oversight to Shared Services Derivatives team supporting RWA operations and production. doi:10.1136/ rmdopen-2017-000578 Prepublication history and More frequently, responsiveness was assessed by correlating changes in the PGA with changes in other scores [23, 50, 58, 77, 78, 81, 83], finding a significant correlation with variations in the SLEDAI (r=0.390.66) [23, 77, 78], SLAM (0.61) [77], LAI (0.56) [77], patient global assessment (0.37) [77], SRI-50 (0.48) [78] and ESR (P<0.0001) [58], but not with C3, C4, circulating immunocomplexes and prednisone dose [77]. , Gomez A . , Kraag GR The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. Patient global assessment in measuring disease activity in rheumatoid , Cappellazzo G We analysed the performance of the SELENA SLEDAI Physician's Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures . [PDF] Use of Physician Global Assessment in systemic lupus , Matos A Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15]. Parodis I . , Engel SM . , Skogh T , Trendelenburg M The .gov means its official. In Fatemi et al. The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. Careers. Methods: Physician global assessment in systemic lupus erythematosus: Can we The literature search identified 91 studies. Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. Complement-Targeted Therapeutics Market Report (2022 to According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. , Raeisi A Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv disease activity). , Sayedbonakdar Z AU - Louthrenoo, Worawit. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. Objective: Disclaimer. Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. In an epratuzumab trial, the absence of deterioration of the PGA (not >10% worsening) was one of the items to achieve a BILAG-based Composite Lupus Assessment (BICLA) response [105]. Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . , Larson MG Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. PGA is often assessed by a single question with a 0-10 or 0-100 response. Feb 2016 - Jan 20182 years. 215 (FIVE YEARS 146) H-INDEX. , Perez-Gutthann S , Lin M http://oml.eular.org/glossary (31 January. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases , Chizzolini C , Altman DG watch for seizures after the procedure. , Annapureddy N , Siega-Riz AM , Seaman AL Supervise the development of junior medical affairs staff . , Mikolaitis-Preuss RA Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. The index assesses separately eight organ-based systems. official website and that any information you provide is encrypted Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. et al. According to the OMERACT, face validity is the degree to which the instrument appears to match with the target domain, according to experts [18]. Physician global assessments for disease activity in rheumatoid arthritis are all over the map! Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Ho LY Vashisht P , Urowitz MB. At a glance: Common scores used in rheumatology Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. , Mohan C. Jolly M Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Unauthorized use of these marks is strictly prohibited. 1 2. The literature search identified 91 studies. Matthew Turk,1,2 Janet E Pope1,2 To cite: turk M, Pope Je. AU - Kandane-Rathnayake, Rangi. , Saad-Magalhes C The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient. , Kandane-Rathnayake RK To increase its reliability, the PGA should be scored by a physician with significant expertise in SLE, with prior knowledge of laboratory results [112], considering the overall disease activity at the time of the visit and comparing it to the last visit in order to assess flares [9]. , Sengupta M Correlations with other instruments measuring similar constructs should typically demonstrate a coefficient (r) 0.50 [106]. , Henriques C , Bentow C Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. et al. Enocsson H Ragai Kiriakos, MD, MSc - Clinical Trials Physician - LinkedIn Systemic Lupus Erythematosus (SLE) Treatment & Management - Medscape The company serves physicians and patients. All rights reserved. Mokkink LB The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials. RMD Open 2018;4:e000578. [84] expressed the sensitivity in PGA scoring with the standardized response mean (SRM), demonstrating a very large effect size (ES=2.23) [110]. Merrill JT , Garabajiu M , Sadovici-Bobeica V 2. BICLA responders had fewer lupus-related serious . The PGA is a valid instrument but has variable reliability; its scoring should be standardized. , Petri M. Iaccarino L , Rairie JE , Roberts WN , Block JA RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. The quantification of reliability is expressed by a correlation coefficient. OBJECTIVE The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI.

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